Cluster of Projects
funded by H2020 Topic FNR-11-2020: Prospecting aquatics and terrestrial natural biological resources for biologically active compounds
The cluster of Algae4IBD, InnCoCells and SECRETed projects aims to address common challenges and will follow joint dissemination and communication activities. The cluster will add value to each project individually and the cluster as a whole.
Algae4IBD’s mission is to develop commercial products for Inflammatory Bowel Disease (IBD) prevention and treatment using aquatic natural biological resources. With the emerging developments in natural product, notable success has been achieved in discovering natural products and their synthetic structural analogues with anti-inflammatory activity. However, global biodiversity remains a largely unexploited resource for natural bioactive molecules with an enormous potential for developing commercial products with public health benefits. Micro and macroalgae, found in marine and freshwater, have been identified as promising sources of bioactive compounds including small molecules and secondary metabolites with a wide range of bioactivities as an antioxidant, anti-inflammatory and cancer preventive. Consumption of algae could, therefore, provide defence against chronic inflammatory diseases such as IBD, that until date have no effective cure. This project offers nature to bedside approach, using an entire development along the value chain for a new biodiscovery therapeutic approach by developing and examining algae-based compounds for IBD patients while guaranteeing algae’s biodiversity preservation. We propose innovative solutions for increasing the use of algae-based ingredients and to ensure the science-based improvement of nutritional quality and its effect on public health. The researchers, companies and hospitals involved in the different stages of the project will use the biodiversity of algae, both micro and macro, as a wide source for bioactive compounds using state-of-the-art cultivation and extraction technologies for obtaining sufficient amounts of the bio-active molecules together with novel processing protocols. It will result in novel algal-based, high-quality bioactive compounds at GMP grade and lower costs for dual purposes – IBD prevention and treatment in relevance to the food as well as the pharmaceutical industries.
The InnCoCells project will develop innovative and sustainable plant-based production processes for the commercial exploitation of scientifically validated cosmetic ingredients based on underutilised plant resources. We will optimise these resources for profitable and sustainable production using cell cultures, aeroponics and greenhouse/field cultivation. We will apply systematic approaches including metabolic engineering tools to optimise growth conditions and the yields of valuable bioactive, small-molecule compounds and ingredients. The optimised processes will be demonstrated by pilot-scale production and subsequent product extraction/purification. We will bring at least ten cosmetic ingredients to the pre-commercial stage. InnCoCells includes a cascade biorefinery concept in which by-products and biowaste are utilised for the extraction of further bioactive molecules. The processes will be characterised by techno-economic assessment and life cycle analysis to ensure economic feasibility and a reduced environmental footprint. The ingredients and extracts will be evaluated using a unique panel of innovative enzyme-based and cell-based assays to ensure safety and validate claimed activities based on robust scientific data without animal testing. We will implement a unique stakeholder engagement strategy, including the assembly of a Stakeholder Group to guide our research program based on the needs of industry, academia, farmers, policymakers and consumers. The consortium includes eight SMEs and one large company from the cosmetic sector among the 17 partners to facilitate exploitation. We will develop bespoke communications strategies for different stakeholders and for public engagement. We will also interact closely with the regulatory authorities in Europe. This industry-driven and interdisciplinary project will ultimately increase the strength of the European bioeconomy by supporting the development of innovative biobased goods and markets.
MARBLES will use a novel and systematic approach to access and exploit marine microbial biodiversity for sustainable bioprospecting to discover microbial consortia and bioactive molecules for application in aqua- and agriculture and in the clinic. MARBLES’ ecology-based bioprospecting strategy will focuses on unique host-microbe interactions in marine environments, including marine sponges, microalgae and fish, which rely on their microbiomes and microbial natural products for disease resistance. Partners’ existing microbial collections and new ones generated during MARBLES will be harnessed for the discovery of novel natural products and synthetic microbial communities. For this, MARBLES will use a systems-wide genomics approach to uncover the bioactive agents in disease-suppressive microbiomes. Also, MARBLES will explore host- and microbe-derived chemicals that elicit production of bioactive compounds, as elicitors to revitalise drug screening. The deliverables will be microbes and consortia and bioactive natural products, their derivatives and elicitors, which can be harnessed to fight infectious diseases in the agrochemical and aquaculture industries and in healthcare.
Besides highly innovative, the approaches will be cost-effective and will offer advantages from both environmental and health perspectives in comparison to existing alternatives. The sustainable production of bioprotectants will increase the effectiveness of fish production – reducing the pressure on harvesting wild fish – and aid the transition of the crop agriculture sector towards bio-based and circular solutions. MARBLES will work closely together with a panel of SMEs and large companies from the EU aquaculture, crop protection biotechnology and health sectors. MARBLES fully complies with the Nagoya and Cartagena Protocols, and aims to make major contributions to the UN sustainable development goals, SDG 2, 3, 12, 13 and 14, as well as to current UN processes (BBNJ, DSI, SynBio)
Link to the Project: https://marblesproject.eu/
Topic: FNR-11-2020 Prospecting aquatic and terrestrial natural biological resources for biologically active compounds