SECRETed Project

10 Work Packages

Leader: IDE R&D

The objective of this workpackage is to ensure compliance with the “ethics requirements” set out in this workpackage.
Leader: MATIS

This WP focuses on developing and applying a range of high-throughput approaches for siderophore and biosurfactant biodiscovery. The objectives of this work package are to assemble provided diverse microbial collections; to select and optimise culture-based and culture-independent methods for screening procedure; to identify and explore taxonomical groups with active production of for biosurfactants and siderophores; and to identify the genetic elements in charge of the synthesis of targeted biosurfactants and siderophores.
Leader: IDE R&D

This work package combines activities aimed to obtain genetic combination designs to produce new tailor-made biocompounds. Specifically, WP3 aims to:
  • the development of machine learning algorithms to survey databases and collect pathways.
    genetic information, molecular structures and properties of biosurfactants and siderophores.
  • the definition and construction of biosurfactant and siderophores chemical space.
  • the identification of major molecular structures with interesting properties.
  • the implementation of inverse QSAR/QSPR modelling approach.
Leader: USE


The aim of this WP is to engineer bacterial strains with the capacity of overproducing new chemical designs. The specific goals include:
  • adaptation and optimisation of standardised vectors in extremophilic model organisms
  • the development of “ready to use” microbial strains and model-driven strain designs 
  • experimental validation of metabolism and gene expression model.
Leader: UoA


In this WP protocols for production of small-scale quantities, from strains derived in WP1 and WP4 will be accomplished together with isolation and characterisation of biosurfactants and siderophores.

  • Evaluation of the state of the art on extraction and purification procedures.
  • Standardised protocols for chemical characterisation.
  • Determination of novel biosurfactant and siderophore chemical.
Leader: BBEPP

The high-performing strains developed in WP5 will be used during the optimisation of the operating strategy at pilot scale. The main objectives are:

  • Integration of unit operations in mathematical process model.
  • Standardised protocols for chemical characterisation.
  • Core processes demonstration at pilot scale.
Leader: SE

The overall goal of this WP is to characterise, analyse and investigate the efficacy of the identified bio-surfactants in the different end-user fields (oncology, gene delivery, cosmetic, house-hold and personal care, food industry/nutrition, agriculture) of the present consortium. WP7 includes the following methods and tests:

  • Integration of unit operations in mathematical process model.
  • Bio-surfactants drug encapsulation, efficacy and toxicity profiles.
  • Novel encapsulation approaches for different end-user applications.
  • Immunomodulatory and anti-tumorigenic capacity of selected compounds.
  • Efficacy of bio-compounds as chelating agents.
Leader: Blue Synergy

  • Quantification and evaluation of environmental effects by the proposed technologies and products.
  • Estimation of capital and operating expenses, cost-effectiveness and competitiveness of proposed solutions.
  • Social impacts and social return of investment assessment.
  • Consumer perception study, awareness campaigns and social acceptance analysis

This work package aims to boost SECRETed’s impact and facilitate the introduction of the results to the market.

  • Dissemination and communication of project’s results and messages to target audiences: stakeholders and general public.
  • Detailed exploitation roadmap (Plan for Exploitation and Dissemination of Results) to bring project results to the market.
  • Mapping and management of the intellectual property rights.

Leader: IDE R&D

The overall objective of this WP is to perform the project coordination and management according to the management structure and decision-making mechanisms of established for the SECRETed project.